Like many indigenous American groups, Huichols have traditionally used the peyote (hikuri) cactus in religious rituals. Because of the visions and effects of the plant, the shaman is able to speak to the gods and ensure the regeneration of the Huichols' souls.
The Huichol and Tepehuan Indians religion consists of four principal deities, the trinity of Corn, Blue Deer, Peyote and the Eagle, all descended from their Sun God, "Tao Jreeku." Quautlatas, the Tepehuan prophet said: "Peyote is everything, it is the crossing of the souls, it is everything there is. Without peyote nothing would exist". Schaefer has interpreted this to mean that peyote is the soul of their religious culture and a visionary sacrament that opens a pathway to the other deities.
"Mexico's peyote casts mind-bending spell on tourists"
occasioned by classic hallucinogen psilocybin.