Richard Horton, editor-in-chief of The Lancet, wrote in Secrets of a Healthy Society.
"What if governments defined security in a broader way—as the health not only of its people but also its society?
A healthy society is much more than a community in which the causes of disease are minimized.
It is one where, at the very least, human creativity is free to flourish, individuals have the liberty to be who they wish to be (without violating the liberties of others), and the spirit of life (all life and not merely human life) prospers.
The peak period for human creativity is between 30 and 40 years. |
Second, breadth. Original thinkers who can foster healthy societies will not worship geekery. To solve global problems, people will need to look beyond the knowledge they have mastered.
They will have to seek insights between disparate disciplines in ways that our current educational apparatus disincentivises.
Third, the ability to frame new questions. What matters is not problem solving. It is problem finding. |
Elizabeth Warren: Change Can Happen, Quit Bedding with Billionaires
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Finally, openness. Never close your mind. Enjoy the idea of ideas. Bask in a sea of hypotheses."
- Inefficient, expensive healthcare system in the United States that bankrupts the middle class and is a barrier to utilization for lower income citizens.
- Neglect and futility in treating mental illness in the United States and overprescribing of addictive psychoactive drugs: Poor understanding and overtreatment of centralized pain with opioids is no different than our poor understanding and mistreatment of mental illness and behavioral issues with antidepressants, benzodiazepines, and antipsychotics. The opioid overdose problem is an epidemic that medicine made, medicine that is the most expensive and least efficient healthcare system in the world.
How America is Killing ItselfPoliticians Lack Either Moral Courage or Intelligence: http://www.ouramazingworld.org/science/addictingamericaPerhaps a Cultural Issue: bit.ly/1ZOOdpNOr Greed? bit.ly/1R8okvfPrescription Opioid Epidemic, Crackdown, No Harm Reduction ==> Heroin use====> Hepatitis C epidemic
Posted by Our Amazing World on Wednesday, February 17, 2016
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NEJM: "But treatment providers in abstinence-oriented programs and their government allies never accepted indefinite maintenance, and their moral and political reservations kept the issue simmering. It simmers still, despite the 2002 approval by the Food and Drug Administration of new products containing buprenorphine, a partial opioid agonist.
The lack of resolution has hindered another important medical task — tertiary prevention by minimizing harm in cases of firmly established opioid addiction. The key objectives — reducing fatal overdoses, medical and social complications, and injection-drug use and related infections — are difficult to achieve if abstinence-oriented treatment is the only option available. Yet that remains the situation in many places, particularly in rural locales, where officials dismiss methadone and buprenorphine as unacceptable substitute addictions. “IF YOU WANT PROBATION OR DIVERSION AND YOUR ON SUBOXIN,” declared an erratically spelled sign outside a Kentucky courtroom, “YOU MUST BE WEENED OFF BY THE TIME OF YOUR SENTENCING DATE.” More from NEJM: Threading the Needle — How to Stop the HIV Outbreak in Rural Indiana American culture has never been comfortable with harm reduction: The prescription opioid epidemic led to a heroin epidemic, which created a hepatitis C epidemic. A life-saving cure for hepatitis C was discovered a few years ago, but 90% of hepatitis C patients cannot be treated because of the price of the drug. The Medicare budget for hepatitis C went from $300 million to $4.5 billion, overnight. More on this below.
NOTE: The hepatitis C epidemic and HIV outbreak in Indiana convinced the culturally-opposed House Republicans to lift a ban on Federal funding for syringe exchanges in December 2015.
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Hidden Costs of the Opioid Epidemic - Hep C drug costs#RxProblem w/o Harm ReductionSee: http://www.ouramazingworld.org/science/addictingamericaPrescription Opioid Epidemic==> Heroin Epidemic====> Huge Spike in Hepatitis C Life-Saving Cure Discovered a Few Years Ago, but 90% of Hepatitis C Patients Cannot Be Treated Because of the Price of the Drug. Medicare budget for Hepatitis C: Went from $300 million to $4.5 billion, overnight. Medicare, Medicaid, VA, and DoD budgets exceeded, Prisoners can't be treated, etc. - - - - - - -Senate Special Committee on Aging 1.usa.gov/1QqaeEgStatement from ASHP: http://www.ashp.org/DocLibrary/Advocacy/GAD-Statement-For-Aging.pdfPharmacists Urge Transparency, Payment Updates as Congress Examines Generic Price SpikesPharmacy Times: bit.ly/1UjHjBS- - - - - - -Ways to protect the public...Dr. GERARD ANDERSONProfessor, Health Policy And Management, Medicine, And International Health, Johns HopkinsGeneric: Important to have competitionBrand: In the brand area, it’s very important to take a look at the patents, when they’re appropriate, when they’re not appropriate, and essentially how long they should be. Because right now, the patent law was originally established during the George Washington administration and was originally for 14 years for 2 years and 2 indentured servants. And now, it’s 17 and 20 years and it’s not reflective of the investment that a drug company makes. Sometimes they invest a lot. Sometimes they invest a little. We need to support the investments and we might want to figure out how to do that differently.MARK MERRITTPresident & CEO, Pharmaceutical Care Management AssociationWell, government has a real important role hear, obviously. It’s a huge purchaser. And we think the role is more in ensuring competition, making sure that there are safe products on the market, that people are getting the products that they think they’re getting, insurance that they think they’re getting, and so forth. And on the purchasing side, the challenge that we see is that it’s such a complicated, fast-moving market. Just like what we did with Imprimis Pharma, this little compounding pharmacy. We found that kind of in real time and it helped drop the price of the products significantly. And the challenge, if you look at price controls or price interventions, direct negotiations, there are kind of two ways to do it. One, you could peg prices to the market and get a discount on it, which does save money for public programs, but will increase costs elsewhere. Or you can kind of just make the price drug by drug. And the danger there, ironically, is that you can end up overpaying. As we saw in this Turing thing…I know it’s a temporary solution, but, if a drug’s $5,000 a day, it might seem good to charge $2500 tomorrow, or maybe even $100. But, little did anybody know, you can get the same drug, basically, for $1. And so, I think we all want to find ways to reduce costs and there are ways government can help.WARREN: No matter how the drug industry sugarcoats it, the America pays the highest for drug prices in the world. And it’s not impossible to fix, and it doesn’t have to be partisan. Just last month, Congress passed legislation that created a new Medicaid inflation rate for generic drugs, which will require drug companies to rebate money when their prices go up faster than the inflation rate. So we’ve got a lot that we could be doing here. I want to talk more about other countries, but the chairwoman is rightly trying to hold us to our 5 minutes. So I’ll just say thank you very much. You’ve laid out good steps…things we need to investigate. Thank you for starting this.Committee Members:https://www.govtrack.us/congress/committees/SPAGPharm Exec's 2015 Brand of the Year: Sovaldi and Harvoni for Hepatitis Chttp://www.pharmexec.com/pharm-execs-2015-brand-year-sovaldi-and-harvoni-hepatitis-cPew Urges Senate Committee on Aging to Maintain Drug Safety Standardshttp://www.pewtrusts.org/en/research-and-analysis/speeches-and-testimony/2015/12/pew-urges-senate-committee-on-aging-to-maintain-drug-safety-standardsSenate Committee Scrutinizes High Drug Priceshttp://www.usnews.com/news/articles/2015/12/08/skyrocketing-prices-for-generic-drugs-compromise-health-carehttp://www.policymed.com/2015/12/senate-aging-committee-hearing-on-drug-prices-faster-generics-approval-could-cut-drug-costs.htmlFirst hearing on drug prices by US senate committeehttp://link.springer.com/article/10.1007/s40274-015-2669-6
Posted by Our Amazing World on Saturday, January 23, 2016
Tennessee fails its citizens like no other state in the Union.
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National Geographic Southern Justice,
"Within 10 days, three pharmacies are robbed of prescription painkillers. Sheriff's deputies and detectives try to determine if a single suspect is responsible for all three robberies. The thief gets away with tablets of prescription painkillers including Oxycontin, nicknamed 'hillbilly heroin.'" NEW IMAGES: Johnson City Walgreens armed robbery suspect possibly connected to similar case in Gray JCPD search for Walgreen’s robbery suspect Man wearing surgical scrubs, mask accused of robbing Walgreens pharmacy Caught on video: 2nd Johnson City Walgreen's robbed 6 days after 1st Man Disguised in Calamine Lotion Robs Pharmacy |
SPECIAL REPORT: Rx Marks the Spot - If you or a loved one you know is dealing with substance abuse and would like some...
Posted by WJHL on Monday, November 2, 2015
Learn about the single payer system and the direction American healthcare must take. This video describes how Big Pharma and insurers lobbied against Americans having a less expensive public option for care. It should start with mental health care.
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Quoting a 2014 story from The Atlantic, "The United States healthcare system is the most expensive in the world, but when it comes to health outcomes, it performs worse than 11 other similar industrialized nations, according to a 2014 report by the Commonwealth Fund.
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Top 2 healthcare priorities in a recent Kaiser health tracking poll:
- Making sure expensive drugs for chronic conditions (i.e. asthma, mental illness, cancer, ulcerative colitis, Crohn's, HIV, hepatitis) are available to those who need them.
- Government action to lower prescription drug prices
Our current healthcare system only benefits top income earners while burying most United States citizens under insurmountable debt if they ever have to utilize the system.
The Affordable Care Act (Obamacare) will not fully work unless there is a single payer national healthcare system where government can negotiate a reasonable price for healthcare services and prescription drugs. Create a healthcare tax and initiate radical healthcare reforms that do not hurt the struggling middle class.
Version 1.0 of the Affordable Care Act is unsustainable. However, the previous healthcare system was much worse. Those with chronic health conditions like asthma and Crohn's disease could simply be denied health insurance and prescription drug coverage due to a preexisting condition. Still, we need to do more, and do it better. Senator Bernie Sanders explained it best in his speech at Georgetown:
"Medicare-for-all would not only guarantee health care for all people, not only save middle class families and our entire nation significant sums of money, it would radically improve the lives of all Americans and bring about significant improvements in our economy."

Implementing a single payer system in mental health care would allow rigorous trials to be conducted to determine the effectiveness of non-drug therapies. It would create jobs in the mental health sector and ensure proper mental health care for Americans in rural and low-income communities with few behavioral health providers.
Study psychotherapies that are assisted with serotonin 2a receptor agonist psilocybin or kappa-opioid agonist Salvinorin A. Quoting chair of the department of psychiatry at the Hofstra North Shore-LIJ School of Medicine, Dr. John Kane, "I believe we have to separate the politics from the science and make sure that our political decisions are informed by data and by evidence. That has been lacking in recent years. We need much more information that people can use. There are always risks and benefits. We have compounds that may have abuse potential but may also have some valuable therapeutic indications."
Even the Veterans Affairs System, arguably the best healthcare system in the United States, cannot provide adequate mental health care for veterans.
Stripes: VA care hard to get for mental health
In terms of psychoactive drugs, the American system allows way more harm to be done than good. It is well known that guidelines for treating pain and mental illness have been weighted heavily toward pharmaceutical company interests.
In the United States, it has resulted in overprescribing of expensive prescription opioids, benzodiazepines, antidepressant, and antipsychotics, while limiting insurance reimbursement of non-drug therapies |
"Opiates, for your baby, too." |
On the contrary, psychiatric medications work only half the time, are expensive, and have the potential to cause side effects such as impotence, addiction, and weight gain. Morbidity from suicide has not decreased in the past 50 years and has increased the last ten. Self-treating subclinical to mild anxiety and depression with alcohol and doctor-supplied prescription opioids harms thousands. 24,000 Americans died from prescription opioid and heroin overdose in 2013 alone.
Politics and the War on Drugs: ""Drugs" is a word that has polluted the well of language. Part of the reason we have a drug problem is because we don't have an intelligent language to talk about substances, plants, psychedelic [and] sedative states of mind, states of amphetamine excitation. We can't make sense of the problem and the opportunities offered by substances unless we clean up our language.
See:

So it's a kind of a paradox isn't it?
"Drugs" mean that which cures us and the greatest social problem of the generation.
Apparently there are "good drugs" sanctioned by science and medicine and "bad drugs" used by brown people in strange rites and growing in unusual plants in distant parts of the world. This kind of thinking, because it's naive, leads of course to social problems and bad politics and bad social policy.
Stars and Stripes: Budget bill forces VA to review policy on medicinal marijuana
Every society chooses a small number of substances, no matter how toxic, and enshrines them in its cultural values, then demonizes all other substances and then persecutes and launches witch hunts against those users whenever some political pretext requires...So it's an old game and it's been played in many places."
U.S. News: America Wakes Up to Mental Health
After the Asylum: How America's Trying to Fix Its Broken Mental Health System No Help for Those with Serious Mental Illness: Fraud, Waste, and Excess Profits
Drug War Follies: Prohibition's Last Dance with Mary Jane
VICE: Amphetamine of the Year Treats Binge-Eating Disorder |
Two bills are in the works that could provide great help to those with serious mental illness: Schizophrenia and bipolar disorder with severe mania.
Over-reliance on drug therapies that work only half the time erodes the availability and affordability of non-drug therapies that are first-line treatments for many forms of mental illness. It's easier for doctors and cheaper in the short-term. In the long-term, it's less effective and more expensive to society. |
"Recently my psychiatric journals have been full of glossy ads promoting a new diagnosis, “binge eating disorder.”
A picture of a sad, lonely woman surrounded by junk food sits underneath text introducing me to the diagnosis, encouraging me to ask my female patients if they sometimes regret how much they eat, because they may be ashamed to talk about it.

It’s getting harder to remain unmedicated in the Altered States of America. Street drugs, speed and heroin, have come in, out of the cold, and are now Adderall or Vyvanse, OxyContin or Zohydro as Big Pharma expands into the recreational market. More women are becoming addicted to opiates and dying of overdoses, and more women are taking antidepressants and sleeping pills than ever before." - Psychiatrist Julie Holland, Seattle Times

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Learn from Canada? Adopting their more efficient single payer system would be a start. |
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Loyd is also featured here:
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Johnson City, largest of the Tri-Cities with a population 65,000, is home to 3 of the top 10 Suboxone prescribers in the United States. Suboxone–a combination of buprenorphine and naloxone–is a form of medication-assisted treatment (MAT) to overcome opioid addiction. "MAT has proved to be clinically effective and to significantly reduce the need for inpatient detoxification services (rehab). MAT provides a more comprehensive, individually tailored program of medication and behavioral therapy."
- Improve patient survival and retention in treatment
- Decrease illicit opiate use and other criminal activity among people with substance use disorders
- Increase patients’ ability to gain and maintain employment
- Improve birth outcomes among women who have substance use disorders and are pregnant
CNN reports, "Half (49%) of those addicted to opioid painkillers were able to reduce their drug abuse when taking Suboxone for at least 12 weeks. The success rate dropped to less than 10% [8.6%] once patients stopped taking the drug." The video below, again from Johnson City, shows how a husband and wife can have completely different responses to Suboxone.
Are patients in Johnson City receiving the appropriate level of care that is needed, such as additional medication-assisted treatment options (i.e. methadone clinics) for opioid use disorder and quality mental health care?
Patients are often co-prescribed benzodiazepines with Suboxone, increasing the risk of respiratory depression and death. |
- Benzodiazepines Treat Anxiety, Cause Long-Term Problems
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Continued Questions on Benzodiazepine Use in Older Patients
- The Next Earl of Sandwich, Luke Montagu: Rapid withdrawal and misprescribing of a benzodiazepine leads to £1.35m settlement for Luke Montagu, CEP co-founder
Why is Suboxone the only treatment option in a community that is clearly as high-risk as Johnson City? As the video above shows, Suboxone doesn't work for everyone and is easily diverted into the community. Another option, methadone clinics, do not carry the same risk of drug diversion.
Nov 2015: Two methadone clinics could be coming to Johnson City
Strictly-regulated Opioid Treatment Programs that administer methadone are few and far between in Tennessee. According to the SAMHSA Opioid Treatment Program Directory, the closest OTP to Johnson City and the Tri-Cities region (population 500,000+) is almost 2 hours away in Knoxville. In fact, the two OTPs in Knoxville are the only two in east Tennessee, excluding Chattanooga.
By comparison, Georgia has a 61 OTPs–almost six times as many as Tennessee–spread evenly across the state. Several South Georgia towns such as Vidalia (pop. 10,000), Valdosta (pop. 56,000), Bainbridge (pop. 12,500), 2 in Dublin (pop. 16,000), Waycross (pop. 16,000), and Brunswick (pop. 15,000) have Opioid Treatment Programs.
Neighboring North Carolina has 52 Methadone Clinics. Five alone are located across the mountains less than an hour away in Boone and Asheville.
Leading the Charge: North Carolina Harm Reduction Coalition
2015 CDC Report highlights Opioid Treatment Provider Need:
"Although the number of physicians and programs that provide medication-assisted treatment (MAT) in the U.S. increased from 2003 to 2012, this increase was not enough to adequately address growing opioid abuse and dependence. A new study points to the need to expand access to methadone and buprenorphine to address the opioid addiction epidemic in the U.S."
Conservative local politicians play a role in the lack of care:
Creating Drug Seekers: Baeteena Black, TPRN
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Without adequately funding behavioral health and support systems, government cracked down on pill mills and overprescribing, then implemented electronic prescription drug monitoring programs.
When the prescription opioid supply decreased, users switched to an unregulated and much cheaper opioid–heroin, administered via injection–resulting in increased overdose deaths and infectious disease transmission.
Key findings include:
- Those who abuse or are dependent on prescription opioid painkillers are 40 times more likely to abuse or be dependent on heroin.
- As heroin abuse or dependence has increased, so has heroin-related overdose deaths. From 2002 through 2013, the rate of heroin-related overdose deaths nearly quadrupled.
There were significant increases of heroin use among groups with historically low rates of injectable drug use–women, those with private insurance, higher incomes–groups that have historically high rates of prescription opioid abuse.
NYTimes: Big Pharma disproportionately targets women (1 out of 4 women take psych meds) according to psychiatrist
Heroin use via injection was responsible for an HIV outbreak
in southeastern Indiana and a hepatitis C epidemic that is currently sweeping through Appalachia. |
Click images for sources.
- Claiborne County, TN, jail says most inmates have hepatitis C
- Costly Hepatitis C Drugs Threaten To Bust Prison Budgets
- Minnesota prison inmates sue to access to costly hepatitis C meds
Sovaldi (sofosbuvir) is a new drug that can essentially cure hepatitis C. Made by Gilead Sciences, Inc., Sovaldi costs about $1,000 a pill, or about $84,000 for a patient on a standard, 12-week treatment schedule.
The U.S. is unique among Western countries in that it doesn’t regulate drug prices. One nurse tells the story of what it’s like to watch patients get sicker when they can’t afford a pricey treatment: The True Cost of an Expensive Medication
Liver Disease Stage Req. for Medicaid Coverage of Sovaldi
In an unusual move for a Republican, Indiana governor Mike Pence expedited legislation to allow syringe exchanges, a harm reduction measure that halts infectious disease transmission and increases contact between substance users and the healthcare system.
NOTE: The United States bans federal funding for syringe exchange programs. According to the Huffington Post, "The ban was put in place in 1988, repealed in 2009, and reinstated by Congress in 2011." (NOTE: The Indiana HIV outbreak finally convinced the culturally-opposed House Republicans to do something as simple as lift a ban on Federal funding for syringe exchanges in December 2015)
Politicians acting as moral police do not have the courage to adopt harm reduction measures such as syringe exchanges and/or sterile injection facilities in times of crisis.
What more can being done to help victims of addiction?
Harm reduction is an approach to substance abuse that is based on support rather than punishment. It reduces stigma and encourages greater healthcare system utilization among drug users. Leaders have implemented life-saving intranasal naloxone initiatives, but are slow to adopt other harm reduction programs due to ideological differences and stigma against drug users. Ineffective and stigmatizing "tough on drugs" attitudes still exist in many areas of the United States, especially in areas hard hit with addiction.
What is being done improve care in northeast Tennessee?
- Continuing Education
- Outpatient Opioid Treatment
- Prescribing Practices
- Harm Reduction
- Intranasal naloxone - NEEDED:
- Syringe/needle exchanges that would reduce rates of infectious disease transmission and increase healthcare utilization among heroin users. Injection centers would reduce overdose deaths.

Amount spent annually in the U.S. on the War on Drugs:
- More than $51,000,000,000
- More Drug War Statistics
America's War on Drugs:
- PBS Frontline: Staggering Death Toll of Mexico’s Drug War
A more effective system of drug policy would treat drug use as a public health problem rather than a criminal offense. More compassion and education, less incarceration.
Substance and Shadow: Women and Addiction in the United States
- The Harrison Act and Its Repercussions
- Excerpt: Women & Addiction in the United States–1850 to 1920
- NEJM book review from 1997, before America's #RxProblem
American culture has never been comfortable with harm reduction:

Obama Tells Outdated Opioid Treatment Industry It's Time To Change
"President Barack Obama tackled the opioid epidemic on October 21 by telling health care providers across the country that access to medication-assisted treatment must be expanded.
For decades, those treating opioid addiction ignored the scientific consensus that the best approach involved medications approved by the Food and Drug Administration, coupled with counseling. Instead, the treatment industry insisted on a model known as "abstinence," in which any prescription medication aimed at addressing a patient's opioid use disorder was forbidden."

If they can afford it, patients who visit rehab will first spend time in detox, then learn to trust the higher power of a 12-step program meant to dissolve ego and reduce addictive behaviors. Patients stay for 30 to 90 days and are encouraged to attend daily AA or NA meetings once they are discharged. Click here to learn more about the higher power that the world has used for eighty years to overcome addiction, in addition to the mystical experience occasioned by psilocybin-assisted psychotherapy.
Follow this link for an excellent flow chart titled "Roadblocks to Seeking Treatment for Substance Addiction" that details the difficult process of accessing a rehab facility.
America must rethink how it approaches drugs by shifting funds away from law enforcement and toward support services: Education, prevention, and treatment.
"The top cops in America's four biggest cities said on Wednesday that the war on drugs has failed to keep America safe and that it's time to reform the country's criminal justice system, a view now officially shared by more than 125 other prosecutors, sheriffs, attorneys general, and law enforcement leaders from across the US."
"The war on drugs has been a tremendous failure," Houston Police Chief Charles McClelland said on Wednesday, advocating for treatment instead of prison for drug offenders. "We've got to rethink the equation when we're making young people, especially young people of color in their mid-20s unemployable because they have a high-level misdemeanor or felony on their record for drugs or nonviolent crime and have no vocation, education, or job skills."
Shamanic Medicines: Trying to Help a Broken and Addicted U.S. Mental Health Care System
Mental Health Argument for Psychedelics: The Kennedys, Addiction, and America's Top Psychiatrist American Culture is Not Your Friend: Bernie Sanders Gets Between American Cultural Institutions and the Next Overdose Epidemic |

When will thought leaders seriously consider allowing non-addictive, archaic means of resilience like meditation and psychedelic psychotherapy become a part of American culture? Mistreating chronic pain in the United States helped create the opioid problem, yet cannabis, with evidence of effectiveness against chronic pain, is illegal. We need behavioral health to be under a single payer system or create alternate means of resilience that are accessible for all.
FDA-Approved Drug Therapies & Classic Hallucinogens to Treat Alcoholism: Barriers, Background, and the Latest Research
"We have had a nearly 50-year hiatus in any serious investigation, except for some heroic investigators at a few universities."
"We Need to Study These Drugs."
"My point is not to say that these drugs should be discounted and relegated to the criticism and dismissal similar to that of treatments for which we have no basis for claims of therapeutic efficacy.
Lieberman & Steve Jobs agree: "LSD was
a very important experience to have" |
These psychedelic drugs clearly are pharmacologically active, have profound effects, could be useful for therapeutic purposes, and need to be studied in an intensive and extensive way before an informed determination can be made.
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Given American mental health's epidemic of death, government should fund psychedelic therapy research to generate needed evidence, then support its integration into society. If not, states might take matters into their own hands. The public already has.
CNN: Could this be the next medical marijuana?
Lieberman continues, "I believe that the scientific investigation of mind-altering psychedelic drugs in the 1960s and '70s was a truncated but promising avenue of research, and that these medications, these drugs, could have significant value for a variety of indications if studied adequately."
See: When Robert Kennedy Defended LSD
In his book, Shrinks, Lieberman states, "Perhaps I’m biased, since without psychiatry I might not be alive. As a teenager my depression nearly got the upper hand before I was saved by drugs—a one-two punch of tricyclic antidepressants and tryptamine psychedelics—and I continue to find better living through chemistry.
My trip did produce one lasting insight, though--one that I remain grateful for to this day...I marveled at the fact that [if] such an incredibly minute amount of a chemical...could so dramatically alter my cognition, the chemistry of the brain must be susceptible to pharmacologic manipulations in other ways, including ways that could be therapeutic."
2011. Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness. MacLean. J Psychopharmacology.
Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. Griffiths. J Psychopharmacology. Press Release. 2008. |

2014-2015 American Psychiatric Association President Paul Summergrad sat with Ram Dass (formerly Harvard psychedelics researcher Richard Alpert) for a taped interview that was shown at the 2015 APA Annual Convention that had a spiritual theme: "Psychiatry: Integrating Body and Mind, Heart and Soul."
Uncle Jesse Posted by Our Amazing World on Friday, November 27, 2015
Could plant medicines such as cannabis, psilocybin (from Psilocybe mushrooms), and ayahuasca that are current DEA Schedule I drugs have therapeutic benefit? Cannabis has anti-cancer properties, alleviates seizures in some patients when other drugs fail, and is a safer pain-relief option than opioid analgesics. LSD leapt onto the scene in the 1950s as the most promising drug ever to treat mental illness and addiction.
After a 40 year hiatus, the LSD's serotonin 2a receptor-stimulating counterparts–psilocybin and ayahuasca–are being studied to treat mental disorders such as addiction, anxiety, and depression. A myriad of difficult-to-treat mental disorders are waiting to be researched using treatment with psychedelic psychotherapy. |
Roland Griffiths, PhD, Addiction Pharmacologist, Psychedelics & Spirituality Expert, Recipient of the 2015 Nathan B. Eddy Award from the College on Problems of Drug Dependence Speaker at TedMed2015
Benjamin Franklin, Redacted: Nothing Said to Be Certain but Death and Psilocybin's Potential Benefit to Mental Health Treatment and Research
See: Kary Mullis, Nobel Prize winner for inventing the polymerase chain reaction (PCR) and Mullis on psychedelic problem solving See: America's Greatest Ethnobotanist Richard Evans Schultes Discusses Ayahuasca and the Importance of Plant Medicines Medical Ethics: Is it Unethical Not to Research These Plant Medicines? Psychedelics, Spirituality, and More: A Religious Model for DMT |

And I should mention MDMA for PTSD. In the first study published, the majority of the folks having had received active MDMA therapy no longer qualified for the diagnosis of PTSD anymore. Again, the effect size is much larger than is typically seen with the approved medications that are used to treat PTSD, which don't work very well."
Additional highlights in the interview:
- There are going to be both biological and psychological answers to many of these questions about mechanism with much work to be done. Safety is discussed at 13:00.
Tim's Story and psilocybin research fundraiser: "A recent but still unpublished study at Johns Hopkins demonstrated rapid, substantial, and sustained (lasting up to six months) antidepressant and anxiolytic (anti-anxiety) effects of a single dose of psilocybin in psychologically-distressed patients with life-threatening cancer
diagnoses. This is incredibly exciting. What if we could decrease or avoid altogether the known side-effects (and frequency of consumption) of current antidepressant drugs like SSRIs? This study could help establish an alternative.
Current popular antidepressant medications have significant adverse side effects, with up to 50% of patients failing to respond fully and as many as 30% remaining completely resistant. Psilocybin has been safely consumed by humans for millennia. Despite this, the study of entheogens like psilocybin was blocked for several decades due to political rather than scientific factors. Now, we can finally explore the therapeutic and medical potential of these powerful compounds." The work Tim is hoping to fund "will determine the efficacy of psilocybin in treatment-resistant depression, and will also use cutting-edge brain imaging to clarify the mechanism of action of psilocybin's antidepressant effects. |
"If you can treat anxiety and depression in people that are dying, why do they have to be dying? If people have chronic anxiety about something or depression, it may be that we'll find treatment so that people don't have to be on antidepressants for years and years and years." David Nichols, PhD, Former Distinguished Chair in Pharmacology, Professor Emeritus, Purdue University
Laws Prevent Research to Treat and Prevent Mental Illness and ... |
Why does important mental health research require crowdfunding?
From Michael Pollan's The Trip Treatment in The New Yorker:
Existing pharmaceuticals do not help ease depression and anxiety in homebound older adults. Could psilocybin help to relieve psychological distress in aging baby boomers?

Benefits of Nature...And More Importantly, What Makes Americans Unhappy? A Pew survey found something of a stress gap by race and education. College-educated parents and white parents were significantly more likely than other parents to say work-family balance is difficult. This is a big reason people are having fewer kids or none at all.

Purposes in Children and Elderly, Overused in Adults
Antipsychotics have a number of severe side-effects and have been linked to long-term structural brain abnormalities, but they carry even bigger risks in elderly people. In March, a team of researchers from the University of Michigan examined the records of older veterans from 1998 and 2009 and found that one of out every 27 patients with dementia treated with the antipsychotics Haloperidol or Risperidone died within six months."
MedlinePlus: Many Seniors Given Antipsychotic Meds, Despite Potential Problems (Risks: kidney damage, stroke, and even death)
NY Times: When Crime Pays: J&J’s Drug Risperdal
"Risperdal is a billion-dollar antipsychotic medicine with real benefits — and a few unfortunate side effects. It can cause strokes among the elderly. And it can cause boys to grow large, pendulous breasts; one boy developed a 46DD bust. Yet Johnson & Johnson marketed Risperdal aggressively to the elderly and to boys while allegedly manipulating and hiding the data about breast development."
TIME: Antipsychotics Flood Top 10 Drug Company Settlements
Of the children on Medicaid who receive antipsychotics, 92% receive them for unapproved uses.
92% of Foster Care and Poor Kids Receive Antipsychotics for Unapproved Uses
California Moves To Stop Misuse Of Psychiatric Meds In Foster Care
See the most common side effects of second generation antipsychotics below, described as potentially "unbearable" and include weight gain, drowsiness, menstrual irregularities, decreased sex drive and arousal, akathisia (inability to sit still), insomnia, and dry mouth.
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- "Over the past several years, an increasing number of adults and children in the United States have been treated with antipsychotic medications.1,2
- Antipsychotics are now among the most commonly prescribed and costly classes of medications.3
- In adults, antipsychotic medications have demonstrated efficacy and have been approved by the Food and Drug Administration (FDA) as a primary treatment for schizophrenia4,5 and bipolar disorder6,7 and as an adjunctive treatment for major depressive disorder.8
- In children and adolescents, antipsychotics are indicated for irritability associated with autistic disorder (5-16 years), tics and vocal utterances of Tourette syndrome and bipolar mania (10-17 years), and schizophrenia (13-17 years)."
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"More than two million people in the United States have a diagnosis of schizophrenia, and the treatment for most of them mainly involves strong doses of antipsychotic drugs that blunt hallucinations and delusions but can come with unbearable side effects, like severe weight gain or debilitating tremors.
Now, results of a landmark government-funded study call that approach into question. The findings, from by far the most rigorous trial to date conducted in the United States, concluded that schizophrenia patients who received a program intended to keep dosages of antipsychotic medication as low as possible and emphasize one-on-one talk therapy and family support made greater strides in recovery over the first two years of treatment than patients who got the usual drug-focused care.
The report, to be published on Tuesday in The American Journal of Psychiatry and funded by the National Institute of Mental Health, comes as Congress debates mental health reform and as interest in the effectiveness of treatments grows amid a debate over the possible role of mental illness in mass shootings."
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